Genetic variants associated with sleep disorders

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Genetic variants associated with sleep disorders

OBJECTIVE The diagnostic boundaries of sleep disorders are under considerable debate. The main sleep disorders are partly heritable; therefore, defining heritable pathophysiologic mechanisms could delineate diagnoses and suggest treatment. We collected clinical data and DNA from consenting patients scheduled to undergo clinical polysomnograms, to expand our understanding of the polymorphisms as...

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Two Genetic Variants Associated with Plantar Fascial Disorders.

Plantar fascial disorder is comprised of plantar fasciitis and plantar fibromatosis. Plantar fasciitis is the most common cause of heel pain, especially for athletes involved in running and jumping sports. Plantar fibromatosis is a rare fibrous hyperproliferation of the deep connective tissue of the foot. To identify genetic loci associated with plantar fascial disorders, a genome-wide associat...

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Sleep Disorders Associated with Chronic Kidney Disease

Twenty-six million American adults have Chronic Kidney Disease (CKD). Chronic Kidney Disease is defined as kidney damage for 3 or more months with or without decreased GFR. Chronic Kidney Disease is divided into five stages, from Stage 1 to Stage 5. End-Stage renal disease is the 5th stage of CKD when dialysis is needed to sustain life. Sleep disorders are common and under recognized in advance...

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[Sleep disorders associated with psychiatric diseases].

Sleep is a sensitive indicator of well-being and a helpful early-warning symptom in many psychiatric disorders. Healthy sleep and a balanced sleep-wake rhythm are desirable goals of a salutary conduct of life. Preventive and psychoeducational measures should take up this point. Non-organic sleep disorders are commonly associated with psychiatric diseases such as major depressive disorder, hypom...

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Genetic factors in sleep disorders.

Several sleep disorders have a genetic basis. These conditions include the narcoleptic syndrome, sleep walking, periodic movements in sleep, circadian delay syndromes and familial insomnia. These disorders illustrate different control mechanisms involved in sleep and wakefulness, including those determining the prevalence and timing of NREM and REM activity, somatomotor inhibition and excitatio...

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ژورنال

عنوان ژورنال: Sleep Medicine

سال: 2015

ISSN: 1389-9457

DOI: 10.1016/j.sleep.2014.11.003